Domino process optimized via ab initio study for an alternative access to bicyclic lactams.
Identifieur interne : 000684 ( France/Analysis ); précédent : 000683; suivant : 000685Domino process optimized via ab initio study for an alternative access to bicyclic lactams.
Auteurs : Sébastien Comesse [France] ; Arnaud Martel ; Adam DaïchSource :
- Organic letters [ 1523-7052 ] ; 2011.
Abstract
A totally new acid-free domino process to access highly functionalized bicyclic γ- and δ-lactams starting from commercially available and inexpensive ethoxymethylene derivatives is reported. Mechanisms elucidated by computational calculations led to new reaction conditions that boosted the yields up to 3.5 times higher.
DOI: 10.1021/ol2015225
PubMed: 21710979
Affiliations:
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pubmed:21710979Le document en format XML
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